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Symbol Name ID |
Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2 MGI:96659 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Ataxia |
Myoclonus |
Tremor |
EEG with spike-wave complexes (2.5-3.5 Hz) |
Absent speech |
Intellectual disability |
Epileptic encephalopathy |
Global developmental delay |
Seizure |
Febrile seizure (within the age range of 3 months to 6 years) |
Myoclonic seizure |
| Disease(s) Associated with KCNA2 | |||||||||||
| developmental and epileptic encephalopathy 32 |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to pharmacologically induced seizures |
seizures |
tonic seizures |
abnormal nervous system electrophysiology |
abnormal action potential |
impaired ability to fire action potentials |
abnormal brain wave pattern |
abnormal single cell response |
abnormal inhibitory postsynaptic currents |
abnormal miniature inhibitory postsynaptic currents |
abnormal channel response |
|
| Availability | Mouse Genotype | ||||||||||||
| Kcna2Pgu/Kcna2Pgu | * | ||||||||||||
| Kcna2tm1Tem/Kcna2tm1Tem | |||||||||||||
| Kcna2Pgu/Kcna2+ | |||||||||||||
| Kcna2tm1Tem/Kcna2+ | |||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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